The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Lydia Kasper; Annika König; Paul-Albert Koenig; Mark S. Gresnigt; Johannes Westman; Rebecca A. Drummond; Michail S. Lionakis; Olaf Groß; Jürgen Ruland; Julian R. Naglik; Bernhard Hube

doi:10.1038/s41467-018-06607-1

Nature Communications (Oct 2018)

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Lydia Kasper,
Annika König,
Paul-Albert Koenig,
Mark S. Gresnigt,
Johannes Westman,
Rebecca A. Drummond,
Michail S. Lionakis,
Olaf Groß,
Jürgen Ruland,
Julian R. Naglik,
Bernhard Hube

Affiliations

Lydia Kasper: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute
Annika König: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute
Paul-Albert Koenig: Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, School of Medicine, Technical University of Munich
Mark S. Gresnigt: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute
Johannes Westman: Program in Cell Biology, The Hospital for Sick Children
Rebecca A. Drummond: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology
Michail S. Lionakis: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology
Olaf Groß: Institute of Neuropathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
Jürgen Ruland: Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, School of Medicine, Technical University of Munich
Julian R. Naglik: Mucosal and Salivary Biology Division, King’s College London Dental Institute
Bernhard Hube: Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knoell Institute

DOI: https://doi.org/10.1038/s41467-018-06607-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 20

Abstract

Read online

Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger of NLRP3 inflammasome activation in these cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal