OncoTargets and Therapy (Sep 2022)

A Unique Three-Way Variant Philadelphia Chromosome t(6;9;22)(p21.3;q34;q11.2) in a Newly Diagnosed Patient with Chronic Myeloid Leukemia Responded to Flumatinib

  • Chen L,
  • Zhang J,
  • Yang N,
  • Tan N,
  • Meng D,
  • Zhang F,
  • Qi Y,
  • Wu G,
  • Li Z

Journal volume & issue
Vol. Volume 15
pp. 1033 – 1037

Abstract

Read online

Lili Chen,1 Junling Zhang,2 Na Yang,1 Ningping Tan,1 Di Meng,1 Fei Zhang,1 Yuyang Qi,1 Guangqi Wu,1 Zhenyu Li3 1Department of Hematology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, People’s Republic of China; 2The Medical Department, 3D Medicines Inc., Shanghai, People’s Republic of China; 3Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Zhenyu Li, Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, People’s Republic of China, Email [email protected] Guangqi Wu, Department of Hematology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, 223800, People’s Republic of China, Email [email protected]: Chronic myeloid leukaemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of Philadelphia (Ph) chromosome in more than 90% of patients. However, about 5– 10% of CML patients show a variant Ph translocation, involving one or more chromosomes in addition to 9 and 22. The treatment and prognostic impact of such additional abnormalities is not known. Herein, we report a unique case of a three-way translocation variant in CML and responded to flumatinib.Case Presentation: A 22-year-old Asian female who presented with leukocytosis was diagnosed with CML. Cytogenetic karyotyping analysis showed 46,XX,t(6;9;22)(p21.3;q34;q11.2). She was treated with flumatinib, and MR5.0 (BCR-ABL1 IS≤ 0.001%, international scale) was achieved after three months of continuous treatment.Conclusion: This was the 5th case of t(6;9;22), in particular, a new variant Ph translocation, and the first successful case treated with flumatinib in the world.Keywords: t(6;9;22)(p21.3;q34;q11.2), CML, Philadelphia chromosome, flumatinib, case report

Keywords