Nature Communications (Nov 2020)
Endogenous antisense RNA curbs CD39 expression in Crohn’s disease
- Rasika P. Harshe,
- Anyan Xie,
- Marta Vuerich,
- Luiza Abrahão Frank,
- Barbora Gromova,
- Haohai Zhang,
- Rene’ J. Robles,
- Samiran Mukherjee,
- Eva Csizmadia,
- Efi Kokkotou,
- Adam S. Cheifetz,
- Alan C. Moss,
- Satya K. Kota,
- Simon C. Robson,
- Maria Serena Longhi
Affiliations
- Rasika P. Harshe
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Anyan Xie
- Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Marta Vuerich
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Luiza Abrahão Frank
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Barbora Gromova
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Haohai Zhang
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Rene’ J. Robles
- Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Samiran Mukherjee
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Eva Csizmadia
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Efi Kokkotou
- Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Adam S. Cheifetz
- Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Alan C. Moss
- Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Satya K. Kota
- Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine
- Simon C. Robson
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- Maria Serena Longhi
- Department of Anesthesia, Critical Care & Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-19692-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
CD39 is an ectonucleotidase associated with immunoregulatory function. Here authors show regulation of CD39 expression by an endogenous antisense RNA moiety transcribed from the 3‘ end of CD39/ENTPD1 which when itself is silenced results in amelioration of pathology in an animal model of colitis.
