Nature Communications (Mar 2020)
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants
- Xiang Shu,
- Jirong Long,
- Qiuyin Cai,
- Sun-Seog Kweon,
- Ji-Yeob Choi,
- Michiaki Kubo,
- Sue K. Park,
- Manjeet K. Bolla,
- Joe Dennis,
- Qin Wang,
- Yaohua Yang,
- Jiajun Shi,
- Xingyi Guo,
- Bingshan Li,
- Ran Tao,
- Kristan J. Aronson,
- Kelvin Y. K. Chan,
- Tsun L. Chan,
- Yu-Tang Gao,
- Mikael Hartman,
- Weang Kee Ho,
- Hidemi Ito,
- Motoki Iwasaki,
- Hiroji Iwata,
- Esther M. John,
- Yoshio Kasuga,
- Ui Soon Khoo,
- Mi-Kyung Kim,
- Sun-Young Kong,
- Allison W. Kurian,
- Ava Kwong,
- Eun-Sook Lee,
- Jingmei Li,
- Artitaya Lophatananon,
- Siew-Kee Low,
- Shivaani Mariapun,
- Koichi Matsuda,
- Keitaro Matsuo,
- Kenneth Muir,
- Dong-Young Noh,
- Boyoung Park,
- Min-Ho Park,
- Chen-Yang Shen,
- Min-Ho Shin,
- John J. Spinelli,
- Atsushi Takahashi,
- Chiuchen Tseng,
- Shoichiro Tsugane,
- Anna H. Wu,
- Yong-Bing Xiang,
- Taiki Yamaji,
- Ying Zheng,
- Roger L. Milne,
- Alison M. Dunning,
- Paul D. P. Pharoah,
- Montserrat García-Closas,
- Soo-Hwang Teo,
- Xiao-ou Shu,
- Daehee Kang,
- Douglas F. Easton,
- Jacques Simard,
- Wei Zheng
Affiliations
- Xiang Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Jirong Long
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Qiuyin Cai
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Sun-Seog Kweon
- Department of Preventive Medicine, Chonnam National University Medical School
- Ji-Yeob Choi
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Sue K. Park
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Manjeet K. Bolla
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Joe Dennis
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Qin Wang
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Yaohua Yang
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Jiajun Shi
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Xingyi Guo
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Bingshan Li
- Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University
- Ran Tao
- Department of Biostatistics, Vanderbilt University Medical Center
- Kristan J. Aronson
- Department of Public Health Sciences and Queen’s Cancer Research Institute, Queen’s University
- Kelvin Y. K. Chan
- Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Tsun L. Chan
- Hong Kong Hereditary Breast Cancer Family Registry
- Yu-Tang Gao
- State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Mikael Hartman
- Department of Surgery, National University Hospital
- Weang Kee Ho
- Department of Applied Mathematics, Faculty of Engineering, University of Nottingham Malaysia Campus
- Hidemi Ito
- Division of Cancer Information and Control, Aichi Cancer Center Research Institute
- Motoki Iwasaki
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Hiroji Iwata
- Department of Breast Oncology, Aichi Cancer Center
- Esther M. John
- Department of Epidemiology, Cancer Prevention Institute of California
- Yoshio Kasuga
- Department of Surgery, Nagano Matsushiro General Hospital
- Ui Soon Khoo
- Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong
- Mi-Kyung Kim
- Division of Cancer Epidemiology and Management, National Cancer Center
- Sun-Young Kong
- National Cancer Center Graduate School of Cancer Science and Policy
- Allison W. Kurian
- Departments of Health Research and Policy, School of Medicine, Stanford University
- Ava Kwong
- Hong Kong Hereditary Breast Cancer Family Registry
- Eun-Sook Lee
- National Cancer Center Graduate School of Cancer Science and Policy
- Jingmei Li
- Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore
- Artitaya Lophatananon
- Division of Health Sciences, Warwick Medical School, Warwick University
- Siew-Kee Low
- RIKEN Center for Integrative Medical Sciences
- Shivaani Mariapun
- Cancer Research Malaysia
- Koichi Matsuda
- Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, University of Tokyo
- Keitaro Matsuo
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Kenneth Muir
- Division of Health Sciences, Warwick Medical School, Warwick University
- Dong-Young Noh
- Cancer Research Institute, Seoul National University College of Medicine
- Boyoung Park
- Department of Medicine, Hanyang University College of Medicine
- Min-Ho Park
- Department of Surgery, Chonnam National University Medical School
- Chen-Yang Shen
- College of Public Health, China Medical University
- Min-Ho Shin
- Department of Preventive Medicine, Chonnam National University Medical School
- John J. Spinelli
- Population Oncology, BC Cancer
- Atsushi Takahashi
- RIKEN Center for Integrative Medical Sciences
- Chiuchen Tseng
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Shoichiro Tsugane
- Center for Public Health Sciences, National Cancer Center
- Anna H. Wu
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Yong-Bing Xiang
- State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Taiki Yamaji
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Ying Zheng
- Shanghai Municipal Center for Disease Control and Prevention
- Roger L. Milne
- Cancer Epidemiology Division, Cancer Council Victoria
- Alison M. Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge
- Paul D. P. Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Montserrat García-Closas
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Soo-Hwang Teo
- Cancer Research Malaysia
- Xiao-ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Daehee Kang
- Department of Preventive Medicine, Seoul National University College of Medicine
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Jacques Simard
- Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-15046-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
In breast cancer, genome-wide associations studies (GWAS) have highlighted loci associated with disease risk. Here, the authors perform a meta-analysis of GWAS data from Asian populations, discovering 31 potential new risk loci, 10 of which are validated in an independent disease cohort.
