Nature Communications (May 2018)
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes
- Rizi Ai,
- Teresina Laragione,
- Deepa Hammaker,
- David L. Boyle,
- Andre Wildberg,
- Keisuke Maeshima,
- Emanuele Palescandolo,
- Vinod Krishna,
- David Pocalyko,
- John W. Whitaker,
- Yuchen Bai,
- Sunil Nagpal,
- Kurtis E. Bachman,
- Richard I. Ainsworth,
- Mengchi Wang,
- Bo Ding,
- Percio S. Gulko,
- Wei Wang,
- Gary S. Firestein
Affiliations
- Rizi Ai
- Department of Chemistry and Biochemistry
- Teresina Laragione
- Division of Rheumatology, Icahn School of Medicine at Mount Sinai
- Deepa Hammaker
- Division of Rheumatology, Allergy and Immunology
- David L. Boyle
- Division of Rheumatology, Allergy and Immunology
- Andre Wildberg
- Department of Chemistry and Biochemistry
- Keisuke Maeshima
- Division of Rheumatology, Allergy and Immunology
- Emanuele Palescandolo
- Janssen Pharmaceuticals
- Vinod Krishna
- Janssen Pharmaceuticals
- David Pocalyko
- Janssen Pharmaceuticals
- John W. Whitaker
- Janssen Pharmaceuticals
- Yuchen Bai
- Janssen Pharmaceuticals
- Sunil Nagpal
- Janssen Pharmaceuticals
- Kurtis E. Bachman
- Janssen Pharmaceuticals
- Richard I. Ainsworth
- Department of Chemistry and Biochemistry
- Mengchi Wang
- Department of Chemistry and Biochemistry
- Bo Ding
- Department of Chemistry and Biochemistry
- Percio S. Gulko
- Division of Rheumatology, Icahn School of Medicine at Mount Sinai
- Wei Wang
- Department of Chemistry and Biochemistry
- Gary S. Firestein
- Division of Rheumatology, Allergy and Immunology
- DOI
- https://doi.org/10.1038/s41467-018-04310-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA). Here the authors integrate a variety of epigenomic data to map the epigenome of FLS in RA and identify potential therapeutic targets.
