American Heart Journal Plus (Aug 2022)

Aspirin use is associated with decreased inpatient mortality in patients with COVID-19: A meta-analysis

  • Aswin Srinivasan,
  • Jonathan Brown,
  • Pavitra Parimala Krishnamani,
  • Brendon Cornett,
  • Ramesh Babu Kesavan,
  • Siva T. Sarva,
  • Syed Arman Raza,
  • Waleed Tallat Kayani

Journal volume & issue
Vol. 20
p. 100191

Abstract

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Thromboembolism is a major cause of death in patients who suffer from COVID-19. Studies examining the effects of aspirin (ASA) on mortality relating to this phenomenon have showed conflicting results with varying degrees and certainties of evidence. We performed an aggregate data meta-analysis of fourteen studies encompassing 164,539 COVID-19 patients, which showed a reduced risk of in-hospital mortality associated with ASA use in eight studies that reported risk ratios (RR 0.90; 95 % CI 0.82–0.98; I2 = 27.33 %, P = 0.01), six studies that reported hazard ratios (HR 0.56; 95 % CI 0.41–0.76, P ≤ 0.01; I2 = 85.92 %) and pooled effect size (0.71; 95 % CI 0.59–0.85, P = 0.00, I2 = 91.51 %). The objective of this study is to report the association between low dose ASA and a reduced risk of in-hospital mortality in patients with COVID-19.

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