Nature Communications (Dec 2021)
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response
- Ruhul Amin,
- Anjali Shukla,
- Jacqueline Jufen Zhu,
- Sohyoung Kim,
- Ping Wang,
- Simon Zhongyuan Tian,
- Andy D. Tran,
- Debasish Paul,
- Steven D. Cappell,
- Sandra Burkett,
- Huaitian Liu,
- Maxwell P. Lee,
- Michael J. Kruhlak,
- Jennifer E. Dwyer,
- R. Mark Simpson,
- Gordon L. Hager,
- Yijun Ruan,
- Kent W. Hunter
Affiliations
- Ruhul Amin
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Anjali Shukla
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Jacqueline Jufen Zhu
- The Jackson Laboratory for Genomic Medicine
- Sohyoung Kim
- Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH
- Ping Wang
- The Jackson Laboratory for Genomic Medicine
- Simon Zhongyuan Tian
- The Jackson Laboratory for Genomic Medicine
- Andy D. Tran
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Debasish Paul
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Steven D. Cappell
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Sandra Burkett
- Molecular Cytogenetics Core Facility, National Cancer Institute, NIH
- Huaitian Liu
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Maxwell P. Lee
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Michael J. Kruhlak
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Jennifer E. Dwyer
- Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- R. Mark Simpson
- Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- Gordon L. Hager
- Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH
- Yijun Ruan
- The Jackson Laboratory for Genomic Medicine
- Kent W. Hunter
- Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH
- DOI
- https://doi.org/10.1038/s41467-021-27451-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 23
Abstract
The involvement of nuclear pore proteins in cellular mechanosensing and metastasis is unclear. Here the authors identify that nuclear pore protein NUP210 promotes metastasis through the interaction with mechanotransducer LINC complex protein and chromatin to regulate mechanosensitive genes.
