Animal Models and Better Understanding of “One Medicine”

Abstract

Medical science has long been informed by the study of animal physiology and pathophysiology, both spontaneous and induced. Physiologist Claude Bernard studied dogs to better understand pancreatic, hepatic and cardiovascular homeostasis [1,2]. Best and Banting uncovered the function of insulin through studies in experimental dogs [3]. More recent studies of obesity in cats have found similarities and interesting differences in the manifestation of the adverse effects of overnutrition between cats and humans [4]. The complete sequencing of the human and mouse genomes, and deep sequencing of pig, cattle, dog and cat have opened up the opportunity to systematically compare genetic similarities and differences [5,6]. [...]

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