Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Sheenu Sheela; Sawa Ito; Jeffrey R. Strich; Maura Manion; Celina Montemayor-Garcia; Hao-Wei Wang; Karolyn A. Oetjen; Kamile A. West; Austin J. Barrett; Mark Parta; Juan Gea-Banacloche; Steven M. Holland; Christopher S. Hourigan; Catherine Lai

doi:10.1016/j.lrr.2017.07.001

Leukemia Research Reports (Jan 2017)

Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection

Sheenu Sheela,
Sawa Ito,
Jeffrey R. Strich,
Maura Manion,
Celina Montemayor-Garcia,
Hao-Wei Wang,
Karolyn A. Oetjen,
Kamile A. West,
Austin J. Barrett,
Mark Parta,
Juan Gea-Banacloche,
Steven M. Holland,
Christopher S. Hourigan,
Catherine Lai

Affiliations

Sheenu Sheela: Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Sawa Ito: Stem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Jeffrey R. Strich: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Maura Manion: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Celina Montemayor-Garcia: Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA
Hao-Wei Wang: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Karolyn A. Oetjen: Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Kamile A. West: Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA
Austin J. Barrett: Stem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Mark Parta: Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD 21702, USA
Juan Gea-Banacloche: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Steven M. Holland: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Christopher S. Hourigan: Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Catherine Lai: Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

DOI: https://doi.org/10.1016/j.lrr.2017.07.001
Journal volume & issue: Vol. 8, no. C
pp. 4 – 6

Abstract

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Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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