Nature Communications (Sep 2019)

Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

  • Parthive H. Patel,
  • Clothilde Pénalva,
  • Michael Kardorff,
  • Marianne Roca,
  • Bojana Pavlović,
  • Anja Thiel,
  • Aurelio A. Teleman,
  • Bruce A. Edgar

DOI
https://doi.org/10.1038/s41467-019-12336-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Epithelia are exposed to diverse types of environmental stress, but the mechanisms by which epithelial cells sense stress are not well understood. Here, the authors show that a Nox-ROS-Ask1-MKK3-p38 signaling axis integrates various types of stress to promote intestinal regeneration.