Nature Communications (Jun 2017)
Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth
- Xiumei Hong,
- Ke Hao,
- Hongkai Ji,
- Shouneng Peng,
- Ben Sherwood,
- Antonio Di Narzo,
- Hui-Ju Tsai,
- Xin Liu,
- Irina Burd,
- Guoying Wang,
- Yuelong Ji,
- Deanna Caruso,
- Guangyun Mao,
- Tami R. Bartell,
- Zhongyang Zhang,
- Colleen Pearson,
- Linda Heffner,
- Sandra Cerda,
- Terri H. Beaty,
- M. Daniele Fallin,
- Aviva Lee-Parritz,
- Barry Zuckerman,
- Daniel E. Weeks,
- Xiaobin Wang
Affiliations
- Xiumei Hong
- Department of Population, Center on the Early Life Origins of Disease, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
- Ke Hao
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Hongkai Ji
- Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health Baltimore
- Shouneng Peng
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Ben Sherwood
- Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health Baltimore
- Antonio Di Narzo
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Hui-Ju Tsai
- Department of Pediatrics, Feinberg School of Medicine, Northwestern University
- Xin Liu
- Department of Pediatrics, Feinberg School of Medicine, Northwestern University
- Irina Burd
- Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University School of Medicine
- Guoying Wang
- Department of Population, Center on the Early Life Origins of Disease, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
- Yuelong Ji
- Department of Population, Center on the Early Life Origins of Disease, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
- Deanna Caruso
- Department of Population, Center on the Early Life Origins of Disease, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
- Guangyun Mao
- Department of Population, Center on the Early Life Origins of Disease, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
- Tami R. Bartell
- Mary Ann & J. Milburn Smith Child Health Research Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago
- Zhongyang Zhang
- Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Colleen Pearson
- Department of Pediatrics, Boston University School of Medicine and Boston Medical Center
- Linda Heffner
- Department of Obstetrics and Gynecology, Boston University School of Medicine
- Sandra Cerda
- Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston University School of Medicine
- Terri H. Beaty
- Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health
- M. Daniele Fallin
- Department of Mental Health, Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins University Bloomberg School of Public Health
- Aviva Lee-Parritz
- Department of Obstetrics and Gynecology, Boston University School of Medicine
- Barry Zuckerman
- Department of Pediatrics, Boston University School of Medicine and Boston Medical Center
- Daniel E. Weeks
- Department of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh
- Xiaobin Wang
- Department of Population, Center on the Early Life Origins of Disease, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health
- DOI
- https://doi.org/10.1038/ncomms15608
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Preterm birth (PTB) has high prevalence and PTB infants have greater risk for mortality. Here, Hong and colleagues perform a genome-wide gene × environment interaction analysis and find that maternalCOL24A1variants have a significant interaction with maternal pre-pregnancy obesity in increasing PTB risk.
