Renin-angiotensin system antagonists, glomerular filtration rate and blood pressure

Abstract

The article deals with the mModern data on the influence of renin-angiotensin system blockers on the glomerular filtration rate, the level of arterial pressure and the outcome of chronic kidney disease. The strategy of rennin-angiotensine blockade is offered to be changed depending on the criteria va­lues of glomerular filtration rate: a combination of inhibitors of angiotensin-converting enzyme + angiotensin receptors blo­ckers, monotherapy and drug withdrawal in glomerular filtration rate under 15–30 ml/min/m2. The formula BRIMONEL for treatment of chronic kidney disease is given.

Keywords

• renin-angiotensin system antagonists
• glomerular filtration rate
• blood pressure
• chronic kidney disease
• the relationship of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and glomerular filtration rate