Nature Communications (Mar 2022)
Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue
- Haofeng Wang,
- Yunjie Xiao,
- Xia Chen,
- Mengwen Zhang,
- Guangxin Sun,
- Feng Wang,
- Lin Wang,
- Hanxiao Zhang,
- Xiaoyu Zhang,
- Xin Yang,
- Wenling Li,
- Yi Wei,
- Deqiang Yao,
- Bing Zhang,
- Jun Li,
- Wen Cui,
- Fenghua Wang,
- Cheng Chen,
- Wei Shen,
- Dan Su,
- Fang Bai,
- Jinhai Huang,
- Sheng Ye,
- Lei Zhang,
- Xiaoyun Ji,
- Wei Wang,
- Zefang Wang,
- Mark Hochstrasser,
- Haitao Yang
Affiliations
- Haofeng Wang
- School of Life Sciences, Tianjin University
- Yunjie Xiao
- School of Life Sciences, Tianjin University
- Xia Chen
- School of Life Sciences, Tianjin University
- Mengwen Zhang
- Department of Molecular Biophysics & Biochemistry, Yale University
- Guangxin Sun
- Department of Molecular Biophysics & Biochemistry, Yale University
- Feng Wang
- School of Life Sciences, Tianjin University
- Lin Wang
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Hanxiao Zhang
- School of Life Sciences, Tianjin University
- Xiaoyu Zhang
- School of Life Sciences, Tianjin University
- Xin Yang
- Institute of Life Sciences, Chongqing Medical University
- Wenling Li
- School of Life Sciences, Tianjin University
- Yi Wei
- School of Life Sciences, Tianjin University
- Deqiang Yao
- State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Bing Zhang
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Jun Li
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Wen Cui
- School of Life Sciences, Tianjin University
- Fenghua Wang
- School of Life Sciences, Tianjin University
- Cheng Chen
- School of Life Sciences, Tianjin University
- Wei Shen
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Dan Su
- State Key Lab of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy
- Fang Bai
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Jinhai Huang
- School of Life Sciences, Tianjin University
- Sheng Ye
- School of Life Sciences, Tianjin University
- Lei Zhang
- School of Life Sciences, Tianjin University
- Xiaoyun Ji
- State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University
- Wei Wang
- Institute of Life Sciences, Chongqing Medical University
- Zefang Wang
- School of Life Sciences, Tianjin University
- Mark Hochstrasser
- Department of Molecular Biophysics & Biochemistry, Yale University
- Haitao Yang
- School of Life Sciences, Tianjin University
- DOI
- https://doi.org/10.1038/s41467-022-29273-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Wolbachia induced cytoplasmic incompatibility (CI) is caused by linked pairs of genes named cifA and cifB. Here, authors show that the residues at interfaces of the CidA-CidB complex is crucial for their binding and contribute to the diversity of CI.
