A neural basis for antagonistic control of feeding and compulsive behaviors

Leandra R. Mangieri; Yungang Lu; Yuanzhong Xu; Ryan M. Cassidy; Yong Xu; Benjamin R. Arenkiel; Qingchun Tong

doi:10.1038/s41467-017-02534-9

Nature Communications (Jan 2018)

A neural basis for antagonistic control of feeding and compulsive behaviors

Leandra R. Mangieri,
Yungang Lu,
Yuanzhong Xu,
Ryan M. Cassidy,
Yong Xu,
Benjamin R. Arenkiel,
Qingchun Tong

Affiliations

Leandra R. Mangieri: Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston
Yungang Lu: Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston
Yuanzhong Xu: Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston
Ryan M. Cassidy: Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston
Yong Xu: Department of Pediatrics, Children’s Nutrition Research Center, Baylor College of Medicine
Benjamin R. Arenkiel: Department of Molecular & Human Genetics, Baylor College of Medicine
Qingchun Tong: Brown Foundation Institute of Molecular Medicine of McGovern Medical School, University of Texas Health Science Center at Houston

DOI: https://doi.org/10.1038/s41467-017-02534-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Feeding disorders are often comorbid with compulsive behaviours but the underlying neural circuits are not known. Here the authors demonstrate that glutamatergic and GABAergic projections from the LH to the PVH exert antagonistic effects on grooming and feeding via modulation of PVH neuron activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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