Cutaneous leishmaniasis and related tissue helminthiasis (review)

Abstract

Epidemiology of cutaneous leismaniasis is considered, CL morbidity remains rather high and it is increasing in Uzbekistan. The main medicines in leishmaniasis treatment are pentavalent antimonials which are characterized by toxicity and resistance development, and amphotericin B. Amphotericin B is toxic too and has a lot of contraindications and side effects. Medicines with reparative and antioxidant properties are assumed to positively influence the CL course, not only leishmanicidal preparations. Protective immunity in CL mediated by Th1 response is analyzed. Expediency of examination of patients with CL for helminthiases inducing opposite Th2-response as well as studies of concomitant helminthiases influence on the CL course are discussed.

Keywords

• cutaneous leishmaniasis
• leishmania
• immune response
• cytokines
• parasitosis