Communications Biology (Oct 2022)
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity
- Md Rasel Molla,
- Akio Shimizu,
- Masahiro Komeno,
- Nor Idayu A. Rahman,
- Joanne Ern Chi Soh,
- Le Kim Chi Nguyen,
- Mahbubur Rahman Khan,
- Wondwossen Wale Tesega,
- Si Chen,
- Xiaoling Pang,
- Miki Tanaka-Okamoto,
- Noriyuki Takashima,
- Akira Sato,
- Tomoaki Suzuki,
- Hisakazu Ogita
Affiliations
- Md Rasel Molla
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Akio Shimizu
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Masahiro Komeno
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Nor Idayu A. Rahman
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Joanne Ern Chi Soh
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Le Kim Chi Nguyen
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Mahbubur Rahman Khan
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Wondwossen Wale Tesega
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Si Chen
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Xiaoling Pang
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Miki Tanaka-Okamoto
- Department of Molecular Biology, Osaka International Cancer Institute
- Noriyuki Takashima
- Division of Cardiovascular Surgery and Thoracic Surgery, Department of Surgery, Shiga University of Medical Science
- Akira Sato
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- Tomoaki Suzuki
- Division of Cardiovascular Surgery and Thoracic Surgery, Department of Surgery, Shiga University of Medical Science
- Hisakazu Ogita
- Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology, Shiga University of Medical Science
- DOI
- https://doi.org/10.1038/s42003-022-04042-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
RhoA is required in vascular smooth muscle cells to inhibit MAP4K4 and prevent abdominal aortic aneurysm formation.
