Nature Communications (Jul 2020)
IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules
- Sara Bisi,
- Stefano Marchesi,
- Abrar Rizvi,
- Davide Carra,
- Galina V. Beznoussenko,
- Ines Ferrara,
- Gianluca Deflorian,
- Alexander Mironov,
- Giovanni Bertalot,
- Federica Pisati,
- Amanda Oldani,
- Angela Cattaneo,
- Ghazaleh Saberamoli,
- Salvatore Pece,
- Giuseppe Viale,
- Angela Bachi,
- Claudio Tripodo,
- Giorgio Scita,
- Andrea Disanza
Affiliations
- Sara Bisi
- IFOM, the FIRC Institute of Molecular Oncology
- Stefano Marchesi
- IFOM, the FIRC Institute of Molecular Oncology
- Abrar Rizvi
- IFOM, the FIRC Institute of Molecular Oncology
- Davide Carra
- IFOM, the FIRC Institute of Molecular Oncology
- Galina V. Beznoussenko
- IFOM, the FIRC Institute of Molecular Oncology
- Ines Ferrara
- Department of Health Sciences, Human Pathology Section, University of Palermo School of Medicine
- Gianluca Deflorian
- Cogentech, S.R.L.
- Alexander Mironov
- IFOM, the FIRC Institute of Molecular Oncology
- Giovanni Bertalot
- European Institute of Oncology (IEO) IRCCS
- Federica Pisati
- Cogentech, S.R.L.
- Amanda Oldani
- IFOM, the FIRC Institute of Molecular Oncology
- Angela Cattaneo
- Cogentech, S.R.L.
- Ghazaleh Saberamoli
- IFOM, the FIRC Institute of Molecular Oncology
- Salvatore Pece
- European Institute of Oncology (IEO) IRCCS
- Giuseppe Viale
- European Institute of Oncology (IEO) IRCCS
- Angela Bachi
- IFOM, the FIRC Institute of Molecular Oncology
- Claudio Tripodo
- IFOM, the FIRC Institute of Molecular Oncology
- Giorgio Scita
- IFOM, the FIRC Institute of Molecular Oncology
- Andrea Disanza
- IFOM, the FIRC Institute of Molecular Oncology
- DOI
- https://doi.org/10.1038/s41467-020-17091-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 23
Abstract
The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.
