Nature Communications (Jul 2019)

Bypassing pan-enterovirus host factor PLA2G16

  • Jim Baggen,
  • Yue Liu,
  • Heyrhyoung Lyoo,
  • Arno L. W. van Vliet,
  • Maryam Wahedi,
  • Jost W. de Bruin,
  • Richard W. Roberts,
  • Pieter Overduin,
  • Adam Meijer,
  • Michael G. Rossmann,
  • Hendrik Jan Thibaut,
  • Frank J. M. van Kuppeveld

DOI
https://doi.org/10.1038/s41467-019-11256-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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The adipose-specific phospholipase A2 (PLA2G16) has been identified as a pan-enterovirus host factor. Here, the authors show that the enterovirus EV-D68-947 can bypass PLA2G16 by using sulfated glycosaminoglycans as alternative glycan receptors and that the interaction induces structural changes promoting viral genome release.