Nature Communications (Jul 2021)
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data
- Matthew C. Altman,
- Darawan Rinchai,
- Nicole Baldwin,
- Mohammed Toufiq,
- Elizabeth Whalen,
- Mathieu Garand,
- Basirudeen Syed Ahamed Kabeer,
- Mohamed Alfaki,
- Scott R. Presnell,
- Prasong Khaenam,
- Aaron Ayllón-Benítez,
- Fleur Mougin,
- Patricia Thébault,
- Laurent Chiche,
- Noemie Jourde-Chiche,
- J. Theodore Phillips,
- Goran Klintmalm,
- Anne O’Garra,
- Matthew Berry,
- Chloe Bloom,
- Robert J. Wilkinson,
- Christine M. Graham,
- Marc Lipman,
- Ganjana Lertmemongkolchai,
- Davide Bedognetti,
- Rodolphe Thiebaut,
- Farrah Kheradmand,
- Asuncion Mejias,
- Octavio Ramilo,
- Karolina Palucka,
- Virginia Pascual,
- Jacques Banchereau,
- Damien Chaussabel
Affiliations
- Matthew C. Altman
- Systems Immunology, Benaroya Research Institute
- Darawan Rinchai
- Research Branch, Sidra Medicine
- Nicole Baldwin
- Baylor Institute for Immunology Research, Baylor Research Institute
- Mohammed Toufiq
- Research Branch, Sidra Medicine
- Elizabeth Whalen
- Systems Immunology, Benaroya Research Institute
- Mathieu Garand
- Research Branch, Sidra Medicine
- Basirudeen Syed Ahamed Kabeer
- Research Branch, Sidra Medicine
- Mohamed Alfaki
- Research Branch, Sidra Medicine
- Scott R. Presnell
- Systems Immunology, Benaroya Research Institute
- Prasong Khaenam
- Systems Immunology, Benaroya Research Institute
- Aaron Ayllón-Benítez
- Inserm U1219 Bordeaux Population Health Research Center, Bordeaux University
- Fleur Mougin
- Inserm U1219 Bordeaux Population Health Research Center, Bordeaux University
- Patricia Thébault
- LaBRI, CNRS UMR5800, Bordeaux University
- Laurent Chiche
- Department of Internal Medicine, Hopital Européen
- Noemie Jourde-Chiche
- Aix-Marseille University, C2VN, INSERM 1263
- J. Theodore Phillips
- Baylor Institute for Immunology Research, Baylor Research Institute
- Goran Klintmalm
- Baylor Institute for Immunology Research, Baylor Research Institute
- Anne O’Garra
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Matthew Berry
- Royal Cornwall Hospitals NHS Trust
- Chloe Bloom
- National Heart and Lung Institute, Imperial College London
- Robert J. Wilkinson
- The Francis Crick Institute
- Christine M. Graham
- Laboratory of Immunoregulation and Infection, The Francis Crick Institute
- Marc Lipman
- UCL Respiratory, Division of Medicine, University College London
- Ganjana Lertmemongkolchai
- Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University
- Davide Bedognetti
- Research Branch, Sidra Medicine
- Rodolphe Thiebaut
- Inserm U1219 Bordeaux Population Health Research Center, Bordeaux University
- Farrah Kheradmand
- Baylor College of Medicine & Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VAMC
- Asuncion Mejias
- Abigail Wexner Research Institute at Nationwide Children’s Hospital and the Ohio State University School of Medicine
- Octavio Ramilo
- Abigail Wexner Research Institute at Nationwide Children’s Hospital and the Ohio State University School of Medicine
- Karolina Palucka
- Baylor Institute for Immunology Research, Baylor Research Institute
- Virginia Pascual
- Baylor Institute for Immunology Research, Baylor Research Institute
- Jacques Banchereau
- Baylor Institute for Immunology Research, Baylor Research Institute
- Damien Chaussabel
- Systems Immunology, Benaroya Research Institute
- DOI
- https://doi.org/10.1038/s41467-021-24584-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
The blood transcriptome of human subjects can be profiled on an almost routine basis in translational research settings. Here the authors show that a fixed and well-characterized repertoire of transcriptional modules can be employed as a reusable framework for the analysis, visualization and interpretation of such data
