Nature Communications (Jul 2021)

Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

  • Matthew C. Altman,
  • Darawan Rinchai,
  • Nicole Baldwin,
  • Mohammed Toufiq,
  • Elizabeth Whalen,
  • Mathieu Garand,
  • Basirudeen Syed Ahamed Kabeer,
  • Mohamed Alfaki,
  • Scott R. Presnell,
  • Prasong Khaenam,
  • Aaron Ayllón-Benítez,
  • Fleur Mougin,
  • Patricia Thébault,
  • Laurent Chiche,
  • Noemie Jourde-Chiche,
  • J. Theodore Phillips,
  • Goran Klintmalm,
  • Anne O’Garra,
  • Matthew Berry,
  • Chloe Bloom,
  • Robert J. Wilkinson,
  • Christine M. Graham,
  • Marc Lipman,
  • Ganjana Lertmemongkolchai,
  • Davide Bedognetti,
  • Rodolphe Thiebaut,
  • Farrah Kheradmand,
  • Asuncion Mejias,
  • Octavio Ramilo,
  • Karolina Palucka,
  • Virginia Pascual,
  • Jacques Banchereau,
  • Damien Chaussabel

DOI
https://doi.org/10.1038/s41467-021-24584-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

The blood transcriptome of human subjects can be profiled on an almost routine basis in translational research settings. Here the authors show that a fixed and well-characterized repertoire of transcriptional modules can be employed as a reusable framework for the analysis, visualization and interpretation of such data