Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Eleni Gkika; Elke Firat; Sonja Adebahr; Erika Graf; Ilinca Popp; Gianluca Radicioni; Simon S. Lo; Ursula Nestle; Nils H. Nicolay; Gabriele Niedermann; Dan G. Duda; Anca-L. Grosu

doi:10.1038/s41698-023-00358-z

npj Precision Oncology (Mar 2023)

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Eleni Gkika,
Elke Firat,
Sonja Adebahr,
Erika Graf,
Ilinca Popp,
Gianluca Radicioni,
Simon S. Lo,
Ursula Nestle,
Nils H. Nicolay,
Gabriele Niedermann,
Dan G. Duda,
Anca-L. Grosu

Affiliations

Eleni Gkika: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Elke Firat: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Sonja Adebahr: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Erika Graf: Institute of Medical Biometry and Statistics, Medical Center—University of Freiburg, Faculty of Medicine
Ilinca Popp: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Gianluca Radicioni: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Simon S. Lo: Department of Radiation Oncology, University of Washington School of Medicine
Ursula Nestle: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Nils H. Nicolay: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Gabriele Niedermann: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine
Dan G. Duda: E. L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School
Anca-L. Grosu: Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine

DOI: https://doi.org/10.1038/s41698-023-00358-z
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 6

Abstract

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Abstract We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment.

Published in npj Precision Oncology

ISSN: 2397-768X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.nature.com/npjprecisiononcology/

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