Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

A. Sahu; H. Mamiya; S. N. Shinde; A. Cheikhi; L. L. Winter; N. V. Vo; D. Stolz; V. Roginskaya; W. Y. Tang; C. St. Croix; L. H. Sanders; M. Franti; B. Van Houten; T. A. Rando; A. Barchowsky; F. Ambrosio

doi:10.1038/s41467-018-07253-3

Nature Communications (Nov 2018)

Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration

A. Sahu,
H. Mamiya,
S. N. Shinde,
A. Cheikhi,
L. L. Winter,
N. V. Vo,
D. Stolz,
V. Roginskaya,
W. Y. Tang,
C. St. Croix,
L. H. Sanders,
M. Franti,
B. Van Houten,
T. A. Rando,
A. Barchowsky,
F. Ambrosio

Affiliations

A. Sahu: Department of Physical Medicine and Rehabilitation, University of Pittsburgh
H. Mamiya: Department of Physical Medicine and Rehabilitation, University of Pittsburgh
S. N. Shinde: Department of Physical Medicine and Rehabilitation, University of Pittsburgh
A. Cheikhi: Department of Physical Medicine and Rehabilitation, University of Pittsburgh
L. L. Winter: Department of Physical Medicine and Rehabilitation, University of Pittsburgh
N. V. Vo: Department of Orthopaedic Surgery, University of Pittsburgh
D. Stolz: Department of Cell Biology, University of Pittsburgh
V. Roginskaya: Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh
W. Y. Tang: Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health
C. St. Croix: Department of Cell Biology, University of Pittsburgh
L. H. Sanders: Department of Neurology, Duke University School of Medicine
M. Franti: Research Beyond Borders: Boehringer-Ingelheim Pharmaceuticals
B. Van Houten: Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh
T. A. Rando: Department of Neurology and Neurological Sciences, Stanford University School of Medicine
A. Barchowsky: Department of Environmental and Occupational Health, University of Pittsburgh
F. Ambrosio: Department of Physical Medicine and Rehabilitation, University of Pittsburgh

DOI: https://doi.org/10.1038/s41467-018-07253-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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While young muscle faithfully regenerates damaged myofibers, aged muscle is impaired. Here the authors show the “anti-aging” protein α-Klotho is upregulated in young muscle after damage via promoter demethylation and this regulation is lost in aging, resulting in mitochondrial damage and an impaired healing response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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