Confined environments induce polarized paraspeckle condensates

Vanja Todorovski; Finn McCluggage; Yixuan Li; Annika Meid; Joachim P. Spatz; Andrew W. Holle; Archa H. Fox; Yu Suk Choi

doi:10.1038/s42003-023-04528-4

Communications Biology (Feb 2023)

Confined environments induce polarized paraspeckle condensates

Vanja Todorovski,
Finn McCluggage,
Yixuan Li,
Annika Meid,
Joachim P. Spatz,
Andrew W. Holle,
Archa H. Fox,
Yu Suk Choi

Affiliations

Vanja Todorovski: School of Human Sciences, The University of Western Australia
Finn McCluggage: School of Human Sciences, The University of Western Australia
Yixuan Li: Mechanobiology Institute, National University of Singapore
Annika Meid: Department of Cellular Biophysics, Max Planck Institute for Medical Research
Joachim P. Spatz: Department of Cellular Biophysics, Max Planck Institute for Medical Research
Andrew W. Holle: Mechanobiology Institute, National University of Singapore
Archa H. Fox: School of Human Sciences, The University of Western Australia
Yu Suk Choi: School of Human Sciences, The University of Western Australia

DOI: https://doi.org/10.1038/s42003-023-04528-4
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 6

Abstract

Read online

In a breast cancer cell line migrating through microchannels, stress-responsive paraspeckle numbers increase under confinement and polarize towards the leading edge.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal