Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease
Mei-Ning Zhu,
Cui-Zhu Zhao,
Chong-Zhi Wang,
Jian-Bo Rao,
Yong-Wei Qiu,
Yan-Ping Gao,
Xiao-Yun Wang,
Ya-Mei Zhang,
Guang Wu,
Jie Chen,
Qin-Ge Ma,
Guo-Yue Zhong,
Rong-Rui Wei
Affiliations
Mei-Ning Zhu
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Cui-Zhu Zhao
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Chong-Zhi Wang
Tang Center for Herbal Medicine Research, The University of Chicago, Chicago 60637, United States; Department of Anesthesia and Critical Care, The University of Chicago, Chicago 60637, United States
Jian-Bo Rao
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Yong-Wei Qiu
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Yan-Ping Gao
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Xiao-Yun Wang
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Ya-Mei Zhang
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Guang Wu
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Jie Chen
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Qin-Ge Ma
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Tang Center for Herbal Medicine Research, The University of Chicago, Chicago 60637, United States; Department of Anesthesia and Critical Care, The University of Chicago, Chicago 60637, United States; Corresponding author at: Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Guo-Yue Zhong
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Corresponding author at: Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Rong-Rui Wei
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine and Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; Corresponding author at: Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Nonalcoholic Fatty Liver Disease (NAFLD) is a serious problem endangering human health in the world. The pathogenesis of this disease is often accompanied by lipid metabolism disorder and can cause liver lipid accumulation. Highland barley Monascus purpureus Went extract (HBMPWE) can inhibit the liver lipid accumulation caused by a high-fat, high-fructose, high-cholesterol diet. However, it is not clear what changes have taken place in the process of liver lipid metabolism after HBMPWE administration. To fill this knowledge gap and to support the findings published in the companion research article entitled “Highland Barley Monascus purpureus Went Extract Ameliorates High-Fat, High-Fructose, High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism in Golden Hamsters” [1], we provided important information related to the liver differential metabolites and identified twenty-one differential metabolites of liver metabolism. In the model group, the levels of lactate, linoleic acid, and malic acid increased significantly. After HBMPWE treatment, the expressions of these metabolites reduced significantly. Therefore, these liver differential metabolites could be used as biological signatures reflecting the severity of NAFLD and HBMPWE treatment outcomes.
