STRUCTURE OF THE POOL OF FREE AMINO ACIDS AND THEIR DERIVATIVES IN PLASMA OF PATIENTS WITH ISHEMIC HEART DISEASE AND CHRONIC CARDIAC INSUFFICIENCY

Abstract

Aim of study – assessment of structure of the pool of free amino acids and related compounds in patients with ishemic heart disease (IHD) depending on the presence of chronic heart insufficiency (CHI) as possessing possible diagnostic value. Material and methods. Amino acid pools were studied by high-performance liquid chromatography in plasma of 45 patients with IHD including 20 patients with CHI and 30 healthy persons. Results. Hyperhomocysteinemia is distinctive for patients with CHI only. Changes in levels of compounds related to amino acid transport to cells (decreased content of total cysteinylglycine, increased – of total cysteine and glutathione) were seen even in absence of CHI. Increased level of serotonin and decreased – of tryptophan in plasma were observed regardless of the CHI. Conclusion. Manifestation of CHI can substantially aggravate the amino acid imbalance existing in blood plasma of patients with IHD.

Keywords

• amino acids
• tryptophan
• serotonin
• homocysteine
• taurine
• ishemic heart disease
• chronic heart insufficiency