Open Chemistry (May 2024)

Acute toxicity and anti-inflammatory activity of bis-thiourea derivatives

  • Umar Muhammad Naveed,
  • Shoaib Muhammad,
  • Ghias Mehreen,
  • Bibi Shakila,
  • Zahoor Muhammad,
  • Khan Sher Wali,
  • Ullah Riaz,
  • Ali Essam A.,
  • Gulfam Naila,
  • Shah Syed Wadood Ali

DOI
https://doi.org/10.1515/chem-2024-0033
Journal volume & issue
Vol. 22, no. 1
pp. 7204 – 18

Abstract

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In the current work, bis-thiourea derivatives have been synthesized through condensation reaction between isothiocynates and diamines in dry acetone to form SK1 (1,2-bis(N-benzoylthioureido) benzene), SK2 (1,3-bis(N-benzoylthioureido) benzene), and SK3 (1,4-bis(N-benzoylthioureido) benzene). The structures of new synthesized derivatives were confirmed through melting point and spectroscopic technique such as 1HNMR only. The synthesized compounds were assessed for acute toxicity test and are proved free of toxicity. The derivatives were further tested as anti-inflammatory agents by in vitro lipoxygenase enzyme inhibition studies, molecular docking, and in vivo carrageenan-induced paw edema assay, and histamine-induced edema test. The overall observations presented that compounds SK1 and SK3 possess promising anti-inflammatory potential, while compound SK2 is found to be a good anti-inflammatory agent.

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