Nature Communications (Mar 2021)

Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease

  • Álvaro Rol,
  • Toni Todorovski,
  • Pau Martin-Malpartida,
  • Anna Escolà,
  • Elena Gonzalez-Rey,
  • Eric Aragón,
  • Xavier Verdaguer,
  • Mariona Vallès-Miret,
  • Josep Farrera-Sinfreu,
  • Eduard Puig,
  • Jimena Fernández-Carneado,
  • Berta Ponsati,
  • Mario Delgado,
  • Antoni Riera,
  • Maria J. Macias

DOI
https://doi.org/10.1038/s41467-021-22076-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Inflammatory bowel disease is caused by chronic inflammation of the gastrointestinal tract and disturbed immune responses. Here the authors present examination of Cortistatin analogues that display enhanced half-life stability whilst maintaining immunomodulatory functionality.