Communications Medicine (Nov 2021)
A case report describing the immune response of an infant with congenital heart disease and severe COVID-19
- Danielle Wurzel,
- Melanie R. Neeland,
- Jeremy Anderson,
- Yara-Natalie Abo,
- Lien Anh Ha Do,
- Celeste M. Donato,
- Julie E. Bines,
- Zheng Quan Toh,
- Rachel A. Higgins,
- Sedi Jalali,
- Theresa Cole,
- Kanta Subbarao,
- Alissa McMinn,
- Kate Dohle,
- Gabrielle M. Haeusler,
- Sarah McNab,
- Annette Alafaci,
- Isabella Overmars,
- Vanessa Clifford,
- Lai-yang Lee,
- Andrew J. Daley,
- Jim Buttery,
- Penelope A. Bryant,
- David Burgner,
- Andrew Steer,
- Shidan Tosif,
- Igor E. Konstantinov,
- Trevor Duke,
- Paul V. Licciardi,
- Daniel G. Pellicci,
- Nigel W. Crawford
Affiliations
- Danielle Wurzel
- Infection and Immunity, Murdoch Children’s Research Institute
- Melanie R. Neeland
- Infection and Immunity, Murdoch Children’s Research Institute
- Jeremy Anderson
- Infection and Immunity, Murdoch Children’s Research Institute
- Yara-Natalie Abo
- Infection and Immunity, Murdoch Children’s Research Institute
- Lien Anh Ha Do
- Infection and Immunity, Murdoch Children’s Research Institute
- Celeste M. Donato
- Infection and Immunity, Murdoch Children’s Research Institute
- Julie E. Bines
- Infection and Immunity, Murdoch Children’s Research Institute
- Zheng Quan Toh
- Infection and Immunity, Murdoch Children’s Research Institute
- Rachel A. Higgins
- Infection and Immunity, Murdoch Children’s Research Institute
- Sedi Jalali
- Infection and Immunity, Murdoch Children’s Research Institute
- Theresa Cole
- Infection and Immunity, Murdoch Children’s Research Institute
- Kanta Subbarao
- Department of Paediatrics, University of Melbourne
- Alissa McMinn
- Infection and Immunity, Murdoch Children’s Research Institute
- Kate Dohle
- Infection and Immunity, Murdoch Children’s Research Institute
- Gabrielle M. Haeusler
- Infection and Immunity, Murdoch Children’s Research Institute
- Sarah McNab
- Infection and Immunity, Murdoch Children’s Research Institute
- Annette Alafaci
- Infection and Immunity, Murdoch Children’s Research Institute
- Isabella Overmars
- Infection and Immunity, Murdoch Children’s Research Institute
- Vanessa Clifford
- Infection and Immunity, Murdoch Children’s Research Institute
- Lai-yang Lee
- Infection and Immunity, Murdoch Children’s Research Institute
- Andrew J. Daley
- Infection and Immunity, Murdoch Children’s Research Institute
- Jim Buttery
- Infection and Immunity, Murdoch Children’s Research Institute
- Penelope A. Bryant
- Infection and Immunity, Murdoch Children’s Research Institute
- David Burgner
- Infection and Immunity, Murdoch Children’s Research Institute
- Andrew Steer
- Infection and Immunity, Murdoch Children’s Research Institute
- Shidan Tosif
- Infection and Immunity, Murdoch Children’s Research Institute
- Igor E. Konstantinov
- Department of Paediatrics, University of Melbourne
- Trevor Duke
- Infection and Immunity, Murdoch Children’s Research Institute
- Paul V. Licciardi
- Infection and Immunity, Murdoch Children’s Research Institute
- Daniel G. Pellicci
- Infection and Immunity, Murdoch Children’s Research Institute
- Nigel W. Crawford
- Infection and Immunity, Murdoch Children’s Research Institute
- DOI
- https://doi.org/10.1038/s43856-021-00047-7
- Journal volume & issue
-
Vol. 1,
no. 1
pp. 1 – 7
Abstract
Wurzel et al. describe the kinetics of the immune response in relation to clinical and virological features in a 5-month old infant with congenital heart disease and severe COVID-19. The immune response was characterised by an elevated inflammatory response in the acute phase of infection, followed by Th2 skewing and prolonged T cell activation.
