GLP-1 localisation and proglucagon gene expression in healthy and diabetic mouse ileum

Abstract

Glucagon-like peptide-1 (GLP-1) is a polypeptide that is mainly produced by intestinal L cells and is encoded by the proglucagon gene. In this study, GLP-1 localisation was investigated in the ileum of healthy and diabetic mice by immunohistochemistry and proglucagon gene expression was assayed by reverse transcription-polymerase chain reaction.

Keywords

• mice
• diabetes mellitus
• glp-1
• l cells
• proglucagon