Effect of pharmacologically induced smooth muscle activation on permeability in murine colitis

Abstract

Background: Both intestinal permeability and contractility are altered in inflammatory bowel disease. Little is known about their mutual relation. Therefore, an in vitro organ bath technique was developed to investigate the simultaneous effects of inflammation on permeability and smooth muscle contractility in different segments of the colon.

Keywords

• Dextran sulphate sodium
• Mice
• Inflammation
• Intestinal permeability
• Intestinal motility.