Monochorionic twins discordant for trisomy 13: A case report, systematic literature search and synthesis of available evidence

Abstract

Abstract This article presents the tenth reported case of monochorionic twins discordant for trisomy 13. Discordant aneuploidies in monochorionic twins are rare. Aetiologies include mitotic error in early cell division and “rescue” chromosome loss in an initially trisomic zygote. Clinicians should offer early amniocentesis of both sacs and consider selective termination.

Keywords

• amniocentesis
• discordant anomalies
• monochorionic twins
• selective termination
• trisomy 13