MicroRNA-34a: A Novel Therapeutic Target in Fibrosis

Min Zhao; Qin Qi; Qin Qi; Shimin Liu; Shimin Liu; Rong Huang; Jiacheng Shen; Yi Zhu; Jing Chai; Handan Zheng; Handan Zheng; Huangan Wu; Huangan Wu; Huirong Liu; Huirong Liu

doi:10.3389/fphys.2022.895242

Frontiers in Physiology (Jun 2022)

MicroRNA-34a: A Novel Therapeutic Target in Fibrosis

Min Zhao,
Qin Qi,
Qin Qi,
Shimin Liu,
Shimin Liu,
Rong Huang,
Jiacheng Shen,
Yi Zhu,
Jing Chai,
Handan Zheng,
Handan Zheng,
Huangan Wu,
Huangan Wu,
Huirong Liu,
Huirong Liu

Affiliations

Min Zhao: Department of Acupuncture-Moxibustion, LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Qin Qi: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Qin Qi: Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China
Shimin Liu: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Shimin Liu: Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China
Rong Huang: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jiacheng Shen: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yi Zhu: Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China
Jing Chai: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Handan Zheng: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Handan Zheng: Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China
Huangan Wu: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Huangan Wu: Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China
Huirong Liu: Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Huirong Liu: Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China

DOI: https://doi.org/10.3389/fphys.2022.895242
Journal volume & issue: Vol. 13

Abstract

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Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been found to play a role in fibrotic diseases. MiR-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates TGF-β1/Smad signal pathway, and negatively regulates the expression of multiple target genes to affect the deposition of extracellular matrix and regulate the process of fibrosis. Some studies have explored the efficacy of miR-34a-targeted therapies for fibrotic diseases. Therefore, miR-34a has specific potential for the treatment of fibrosis. This article reviews the important roles of miR-34a in fibrosis and provides the possibility for miR-34a as a novel therapeutic target in fibrosis.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

About the journal

Abstract

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