Journal of Clinical Medicine (Oct 2021)

Single-Nucleotide Polymorphisms in MICA and MICB Genes Could Play a Role in the Outcome in AML Patients after HSCT

  • Alena Machuldova,
  • Lucie Houdova,
  • Katerina Kratochvilova,
  • Martin Leba,
  • Pavel Jindra,
  • Pavel Ostasov,
  • Diana Maceckova,
  • Robin Klieber,
  • Hana Gmucova,
  • Jiri Sramek,
  • Monika Holubova

DOI
https://doi.org/10.3390/jcm10204636
Journal volume & issue
Vol. 10, no. 20
p. 4636

Abstract

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NKG2D and its ligands, MICA and MICB, are known as the key regulators of NK cells. NK cells are the first reconstituted cells after the allogeneic hematopoietic stem cell transplantation (HSCT); therefore, it is crucial to understand their role in HSCT outcome. In the presented study, we investigated the single amino acid changes across the exons 2–4 of MICA and MICB genes, and point mutations within the NKG2D gene, which defines the type of NKG2D haploblock (HNK/LNK) in the donors (n = 124), as well as in patients with acute myeloid leukemia (n = 78). In our cohort, we found that graft from a donor with at least one MICA allele containing glycine at position 14 (MICA-14Gly) is significantly associated with deterioration of a patient’s overall survival (OS) (p p = 0.069). To our knowledge, this is the first work describing the role of MICA-14 and MICB-58 polymorphisms on HSCT outcome.

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