Medical Mycology Case Reports (Jun 2017)

Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis

  • Isabel Rodriguez-Goncer,
  • Rob Niven,
  • David W. Denning

DOI
https://doi.org/10.1016/j.mmcr.2017.04.005
Journal volume & issue
Vol. 16, no. C
pp. 31 – 33

Abstract

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Severe asthma with fungal sensitization (SAFS) is estimated to affect ~25% of patients with poorly controlled asthma. Tri-azole therapy is effective in only 60–80% and side effects are common. We report a 25 years-old woman with severe asthma, Aspergillus sensitization and marked bronchiectasis that developed a rare Achilles-tendinopathy with both itraconazole and voriconazole. She started a trial with terbinafine as salvage therapy that led to a striking improvement and long-term control of her respiratory disease.

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