Communications Biology (Nov 2022)

Interaction kinetics between p115-RhoGEF and Gα13 are determined by unique molecular interactions affecting agonist sensitivity

  • Fabian Redlin,
  • Anna-Lena Krett,
  • Moritz Bünemann

DOI
https://doi.org/10.1038/s42003-022-04224-9
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

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The three RH-RhoGEFs differ in their sensitivity of activation by G proteins. For p115-RhoGEF, a specific molecular interaction with Gα13 is responsible for faster kinetics and lower sensitivity.