Value of serum procalcitonin, H-FABP and MPV / PLT in prognostic assessment of urosepsis

Abstract

Objective To analyze the levels of serum procalcitonin (PCT) , heart-type fatty acid binding protein (H-FABP) and mean platelet volume to platelet count ratio (MPV/PLT) in patients with urosepsis and their prognostic value. Methods A total of 140 patients with urosepsis admitted to Zhangjiakou First Hospital from March 2020 to March 2022 were selected. The patients were divided into survival group (105 patients) and death group (35 patients) according to whether they were survived 28 d after hospitalization. A total of 30 healthy subjects matched with gender and age of patients with urosepsis were selected as the control group. Levels of PCT, H-FABP and MPV/PLT were compared among the three groups, and the value of each index alone and in combination for predicting the outcome of urosepsis was evaluated. Results The levels of PCT, H-FABP and MPV/PLT decreased in the order of death group, survival group, and control group (P＜0.05) . Logistic regression analysis showed that low SBP and PaO2/FiO2, high PCT, H-FABP and MPV/PLT levels were independent risk factors for poor outcome in urosepsis (P＜0.05) . The areas under the ROC curve of PCT, H-FABP and MPV/PLT alone in predicting the poor outcome of urosepsis were 0.692, 0.860 and 0.674, respectively, and the area under the ROC curre for combined prediction were 0.862. Conclusion Compared with healthy subjects, the levels of PCT, H-FABP and MPV/PLT are abnormally increased in patients with urosepsis, which may be valuable for prognostic evaluation.

Keywords

• procalcitonin
• heart type fatty acid binding protein
• mean platelet volume
• platelet count
• urosepsis
• oxygenation index