Nature Communications (Jul 2021)
Cryo-EM structure of human Wntless in complex with Wnt3a
- Qing Zhong,
- Yanyu Zhao,
- Fangfei Ye,
- Zaiyu Xiao,
- Gaoxingyu Huang,
- Meng Xu,
- Yuanyuan Zhang,
- Xiechao Zhan,
- Ke Sun,
- Zhizhi Wang,
- Shanshan Cheng,
- Shan Feng,
- Xiuxiu Zhao,
- Jizhong Zhang,
- Peilong Lu,
- Wenqing Xu,
- Qiang Zhou,
- Dan Ma
Affiliations
- Qing Zhong
- Fudan University
- Yanyu Zhao
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Fangfei Ye
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Zaiyu Xiao
- Fudan University
- Gaoxingyu Huang
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Meng Xu
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Yuanyuan Zhang
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Xiechao Zhan
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Ke Sun
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Zhizhi Wang
- School of Life Science and Technology, ShanghaiTech University
- Shanshan Cheng
- School of Life Science and Technology, ShanghaiTech University
- Shan Feng
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Xiuxiu Zhao
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Jizhong Zhang
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Peilong Lu
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Wenqing Xu
- School of Life Science and Technology, ShanghaiTech University
- Qiang Zhou
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Dan Ma
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- DOI
- https://doi.org/10.1038/s41467-021-24731-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss mechanistic implications for the palmitoleoylation of Wnt3a that is required for WLS mediated Wnt secretion.
