Frontiers in Microbiology (Jul 2021)
Viral UL8 Is Involved in the Antiviral Activity of Oleanolic Acid Against HSV-1 Infection
- Tianhao Shan,
- Tianhao Shan,
- Tianhao Shan,
- Tianhao Shan,
- Tianhao Shan,
- Tianhao Shan,
- Ju Ye,
- Jiaoyan Jia,
- Jiaoyan Jia,
- Jiaoyan Jia,
- Jiaoyan Jia,
- Jiaoyan Jia,
- Jiaoyan Jia,
- Zhaoyang Wang,
- Zhaoyang Wang,
- Zhaoyang Wang,
- Zhaoyang Wang,
- Zhaoyang Wang,
- Zhaoyang Wang,
- Yuzhou Jiang,
- Yuzhou Jiang,
- Yuzhou Jiang,
- Yuzhou Jiang,
- Yuzhou Jiang,
- Yuzhou Jiang,
- Yiliang Wang,
- Yiliang Wang,
- Yiliang Wang,
- Yiliang Wang,
- Yiliang Wang,
- Yiliang Wang,
- Yifei Wang,
- Yifei Wang,
- Yifei Wang,
- Yifei Wang,
- Yifei Wang,
- Yifei Wang,
- Kai Zheng,
- Zhe Ren,
- Zhe Ren,
- Zhe Ren,
- Zhe Ren,
- Zhe Ren,
- Zhe Ren
Affiliations
- Tianhao Shan
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Tianhao Shan
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Tianhao Shan
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Tianhao Shan
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Tianhao Shan
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Tianhao Shan
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Ju Ye
- Key Laboratory of Plant Chemistry in Qinghai-Tibet Plateau, Qinghai University for Nationalities, Xining, China
- Jiaoyan Jia
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Jiaoyan Jia
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Jiaoyan Jia
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Jiaoyan Jia
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Jiaoyan Jia
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Jiaoyan Jia
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Zhaoyang Wang
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Zhaoyang Wang
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Zhaoyang Wang
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Zhaoyang Wang
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Zhaoyang Wang
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Zhaoyang Wang
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yuzhou Jiang
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yuzhou Jiang
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Yuzhou Jiang
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Yuzhou Jiang
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yuzhou Jiang
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Yuzhou Jiang
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yiliang Wang
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yiliang Wang
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Yiliang Wang
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Yiliang Wang
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yiliang Wang
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Yiliang Wang
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yifei Wang
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yifei Wang
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Yifei Wang
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Yifei Wang
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Yifei Wang
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Yifei Wang
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Kai Zheng
- School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China
- Zhe Ren
- Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- Zhe Ren
- Key Laboratory of Virology of Guangzhou, Jinan University, Guangzhou, China
- Zhe Ren
- Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, Guangzhou, China
- Zhe Ren
- Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China
- Zhe Ren
- Guangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, China
- Zhe Ren
- National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fmicb.2021.689607
- Journal volume & issue
-
Vol. 12
Abstract
Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can cause severe diseases, especially in immunocompromised adults and newborns, such as keratitis and herpes simplex encephalitis. At present, the clinical therapeutic drug against HSV-1 infection is acyclovir (ACV), and its extensive usage has led to the emergence of ACV-resistant strains. Therefore, it is urgent to explore novel therapeutic targets and anti-HSV-1 drugs. This study demonstrated that Oleanolic acid, a pentacyclic triterpenoid widely existing in natural product, had strong antiviral activity against both ACV-sensitive and -resistant HSV-1 strains in different cells. Mechanism studies showed that Oleanolic acid exerted its anti-HSV-1 activity in the immediate early stage of infection, which involved the dysregulation of viral UL8, a component of viral helicase-primase complex critical for viral replication. In addition, Oleanolic acid significantly ameliorated the skin lesions in an HSV-1 infection mediated zosteriform model. Together, our study suggested that Oleanolic acid could be a potential candidate for clinical therapy of HSV-1 infection-related diseases.
Keywords
