The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis

• Yang Liu,
• Feifei Song,
• Xianhuang Zeng,
• Siqi Yang,
• Zixu Zhai,
• Ze Wang,
• Wajeeha Naz,
• Tanzeel Yousaf,
• Junwei Sun,
• Yangjun Zhang,
• Ying Zhou,
• Mingxiong Guo,
• Yun-Bo Shi,
• Geng Tian,
• Guihong Sun

Affiliations

Yang Liu

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Feifei Song

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Xianhuang Zeng

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Siqi Yang

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Zixu Zhai

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China

Ze Wang

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China; Ecological Research Center, College of Science, Tibet University, Lhasa, Tibet 850012, China

Wajeeha Naz

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Tanzeel Yousaf

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Junwei Sun

Department of Hepatic & Biliary & Pancreatic Surgery, Hubei Cancer Hospital, Affiliated Hubei Cancer Hospital of Huazhong University of Science and Technology, Wuhan, Hubei 430079, China

Yangjun Zhang

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China

Ying Zhou

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China

Mingxiong Guo

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China; Ecological Research Center, College of Science, Tibet University, Lhasa, Tibet 850012, China

Yun-Bo Shi

Section on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Corresponding author.

Geng Tian

Department of Oncology, The First Affiliated Hospital of Shenzhen University, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong 518035, China; Corresponding author.

Guihong Sun

Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China; Hubei Provincial Key Laboratory of Allergy and Immunology, Wuhan, Hubei 430071, China; Corresponding author. Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, Hubei 430071, China.