Nature Communications (May 2022)
Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS
- Peng Shi,
- Xiaoyu Ren,
- Jie Meng,
- Chenlu Kang,
- Yihe Wu,
- Yingxue Rong,
- Shujuan Zhao,
- Zhaodi Jiang,
- Ling Liang,
- Wanzhong He,
- Yuxin Yin,
- Xiangdong Li,
- Yong Liu,
- Xiaoshuai Huang,
- Yujie Sun,
- Bo Li,
- Congying Wu
Affiliations
- Peng Shi
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Xiaoyu Ren
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Jie Meng
- Institute of Biomechanics and Medical Engineering, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University
- Chenlu Kang
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Yihe Wu
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Yingxue Rong
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Shujuan Zhao
- State Key Laboratory of Membrane Biology, Biomedical Pioneer Innovation Center (BIOPIC), School of Life Sciences, Peking University
- Zhaodi Jiang
- National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University
- Ling Liang
- Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center
- Wanzhong He
- National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University
- Yuxin Yin
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- Xiangdong Li
- Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences
- Yong Liu
- Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University
- Xiaoshuai Huang
- Biomedical Engineering Department, Peking University
- Yujie Sun
- State Key Laboratory of Membrane Biology, Biomedical Pioneer Innovation Center (BIOPIC), School of Life Sciences, Peking University
- Bo Li
- Institute of Biomechanics and Medical Engineering, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University
- Congying Wu
- Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center
- DOI
- https://doi.org/10.1038/s41467-022-30431-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The structure of the mitochondrial inner membrane, or cristae, is important for functional oxidative phosphorylation and energy production. Here, the authors show that loss of myosin 19 impairs cristae structure as well as energy production, connecting motor activity to membrane potential.
