BMC Research Notes (Jul 2011)

Serum selenium levels do not differ in type 2 diabetic subjects with and without coronary artery disease

  • Apostolou Ourania,
  • Kokkinari Athanasia,
  • Ioannidis Aggelos,
  • Papazafiropoulou Athanasia K,
  • Papadodima Stavroula A,
  • Sotiropoulos Alexios,
  • Spiliopoulou Chara A,
  • Athanaselis Sotirios

DOI
https://doi.org/10.1186/1756-0500-4-270
Journal volume & issue
Vol. 4, no. 1
p. 270

Abstract

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Abstract Background The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD). Methods A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants. Results Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 ± 31.10 vs. 108.86 ± 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05). Conclusion Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.

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