A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery

Sunfan Li; Fangzhou Li; Dong Wan; Zuqin Chen; Jie Pan; Xing-Jie Liang

Bioactive Materials (Jul 2023)

A micelle-based stage-by-stage impelled system for efficient doxorubicin delivery

Sunfan Li,
Fangzhou Li,
Dong Wan,
Zuqin Chen,
Jie Pan,
Xing-Jie Liang

Affiliations

Sunfan Li: School of Chemical Engineering and Technology, Tiangong University, Tianjin, 300387, PR China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, PR China
Fangzhou Li: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, PR China
Dong Wan: School of Chemical Engineering and Technology, Tiangong University, Tianjin, 300387, PR China; Corresponding author.
Zuqin Chen: Medical School of Chinese PLA, No.28 Fuxing Road, Beijing, 100853, PR China; Department of Radiology, The First Medical Centre, Chinese PLA General Hospital, Beijing, PR China; Department of Radiology, Chinese PAP Guangxi Corps Hospital, Nanning, Guangxi, PR China
Jie Pan: School of Chemical Engineering and Technology, Tiangong University, Tianjin, 300387, PR China; Corresponding author.
Xing-Jie Liang: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; Corresponding author. University of Chinese Academy of Sciences, Beijing, 100049, PR China.

Journal volume & issue: Vol. 25
pp. 783 – 795

Abstract

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Chemotherapy remains the mainstay of cancer treatment, benefiting millions of patients each year, but the side effects of chemotherapy drugs severely limit their clinical use. Doxorubicin (DOX) can cause various side effects such as heart damage and treatment-related tumors. The effective use of active and passive targeting will improve the clinical application of DOX. Here, TPGS3350 and bioactive peptides were utilized to construct a micelle-based stage-by-stage impelled efficient system (missiles) for DOX delivery (DOX missiles). By taking advantage of the EPR effect, DOX missiles are efficiently enriched at the tumor site. After being cleaved by matrix metalloproteinase2 (MMP2), the peptide (VRGD) targets tumor cells to facilitate uptake of the missiles by the tumor cells via receptor-mediated endocytosis. The intracellular activated caspase-3-catalyzed explosion of DOX missiles further enables efficient tumor killing. This study provides an efficient approach for DOX delivery and toxicity reduction.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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