Hypoxia-induced SETX links replication stress with the unfolded protein response

Shaliny Ramachandran; Tiffany S. Ma; Jon Griffin; Natalie Ng; Iosifina P. Foskolou; Ming-Shih Hwang; Pedro Victori; Wei-Chen Cheng; Francesca M. Buffa; Katarzyna B. Leszczynska; Sherif F. El-Khamisy; Natalia Gromak; Ester M. Hammond

doi:10.1038/s41467-021-24066-z

Nature Communications (Jun 2021)

Hypoxia-induced SETX links replication stress with the unfolded protein response

Shaliny Ramachandran,
Tiffany S. Ma,
Jon Griffin,
Natalie Ng,
Iosifina P. Foskolou,
Ming-Shih Hwang,
Pedro Victori,
Wei-Chen Cheng,
Francesca M. Buffa,
Katarzyna B. Leszczynska,
Sherif F. El-Khamisy,
Natalia Gromak,
Ester M. Hammond

Affiliations

Shaliny Ramachandran: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Tiffany S. Ma: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Jon Griffin: Department of Molecular Biology and Biotechnology, Healthy Lifespan and Neuroscience Institute, Firth Court, University of Sheffield
Natalie Ng: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Iosifina P. Foskolou: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Ming-Shih Hwang: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Pedro Victori: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Wei-Chen Cheng: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Francesca M. Buffa: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Katarzyna B. Leszczynska: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford
Sherif F. El-Khamisy: Department of Molecular Biology and Biotechnology, Healthy Lifespan and Neuroscience Institute, Firth Court, University of Sheffield
Natalia Gromak: Sir William Dunn School of Pathology, University of Oxford
Ester M. Hammond: Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-24066-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal