Data on carotid intima-media thickness and lipoprotein subclasses in type 1 diabetes from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC)
Arpita Basu,
Alicia J. Jenkins,
Ying Zhang,
Julie A. Stoner,
Richard L. Klein,
Maria F. Lopes-Virella,
W. Timothy Garvey,
Timothy J. Lyons
Affiliations
Arpita Basu
Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA
Alicia J. Jenkins
Section of Endocrinology & Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; University of Sydney, NHMRC Clinical Trials Centre, Camperdown, Sydney, NSW, Australia
Ying Zhang
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Julie A. Stoner
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Richard L. Klein
Division of Endocrinology, Medical University of South Carolina, Charleston, SC, USA; The Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, USA
Maria F. Lopes-Virella
Division of Endocrinology, Medical University of South Carolina, Charleston, SC, USA; The Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, USA
W. Timothy Garvey
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
Timothy J. Lyons
Section of Endocrinology & Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Centre for Experimental Medicine, Queen’s University of Belfast, Belfast, UK; Correspondence to: Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University of Belfast, ICS Block A, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK. Tel.: +44 28 9063 2636; fax: +44 28 9063 5012.
Type 1 diabetes (T1DM) is associated with increased risk of macrovascular complications. We examined longitudinal associations of serum conventional lipids and nuclear magnetic resonance (NMR)-determined lipoprotein subclasses with carotid intima-media thickness (IMT) in adults with T1DM (n=455) enrolled in the Diabetes Control and Complications Trial (DCCT). Data on serum lipids and lipoproteins were collected at DCCT baseline (1983–89) and were correlated with common and internal carotid IMT determined by ultrasonography during the observational follow-up of the DCCT, the Epidemiology of Diabetes Interventions and Complications (EDIC) study, at EDIC ‘Year 1’ (199–1996) and EDIC ‘Year 6’ (1998–2000). This article contains data on the associations of DCCT baseline lipoprotein profiles (NMR-based VLDL & chylomicrons, IDL/LDL and HDL subclasses and ‘conventional’ total, LDL-, HDL-, non-HDL-cholesterol and triglycerides) with carotid IMT at EDIC Years 1 and 6, stratified by gender. The data are supplemental to our original research article describing detailed associations of DCCT baseline lipids and lipoprotein profiles with EDIC Year 12 carotid IMT (Basu et al. in press) [1]. Keywords: Lipids and lipoproteins, Carotid intima-media thickness, Type 1 diabetes
