Protective efficacy of Capsicum frutescens fruits in pancreatic, hepatic and renal cell injury and their attenuation of oxidative stress in diabetic Wistar rats

Abstract

According to our insight, it is the first investigation based on a literature review to establish the oxidative stress defense and hypoglycemic effects of Capsicum frutescens fruits. The anti-hyperglycemic effect of acetone extract of the fruits of C. frutescens (CFA) was imposed at 250mg/kg and 500mg/kg for 21 days in diabetic-induced Wistar rats. The rats were divided into five groups as control, diabetic, diabetic receiving glibenclamide, and two diabetic receiving CFA-treatment groups. Beginning on the 4th day and up to the 21st day of therapy, CFA at 250mg/kg and 500mg/kg demonstrated a substantial decrease in Blood Glucose Levels (BGL). CFA at 500mg/kg led to a considerable decrease in Low-Density Lipoprotein (LDL) cholesterol and a substantial increase in High-Density Lipoprotein (HDL) cholesterol, showing that CFA possesses anti-diabetic properties. Histopathological examinations reveal hepatic, pancreatic, and renal regularization. As a result, the current study clearly demonstrated more important antidiabetic activity of CFA extracts.

Keywords

• capsicum frutescens
• enzymatic antioxidant system
• non-enzymatic antioxidants
• hypoglycemic activity
• streptozotocin (stz) induced diabetes