Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes

Nan Wang; Ying Zhang; Li Xu; Shuilin Jin

doi:10.3389/fnins.2018.01026

Frontiers in Neuroscience (Jan 2019)

Relationship Between Alzheimer’s Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes

Nan Wang,
Ying Zhang,
Li Xu,
Shuilin Jin

Affiliations

Nan Wang: Department of Mathematics, Harbin Institute of Technology, Harbin, China
Ying Zhang: Department of Pharmacy, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, China
Li Xu: College of Computer Science and Technology, Harbin Engineering University, Harbin, China
Shuilin Jin: Department of Mathematics, Harbin Institute of Technology, Harbin, China

DOI: https://doi.org/10.3389/fnins.2018.01026
Journal volume & issue: Vol. 12

Abstract

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Alzheimer’s disease (AD), a neurodegenerative diseases (neuro-diseases) which is prevalent in the elderly and seriously affects the lives of individuals. Many studies have discussed the relationship between immune system and AD pathogenesis. Here, the meta-analysis of differentially expressed (DE) genes based on microarray data was conducted to study the association between AD and immune system. 9519 target genes of hippocampus in 146 subjects (73 AD cases and 73 controls) from 4 microarray data sets were compiled and DE genes with p < 1.00E - 04 were selected to conduct the pathway-analysis. The results indicated that the DE genes were significantly enriched in the neuro-diseases as well as the immune system pathways.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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