MedComm (Mar 2025)
Noninvasive Quantification of Hepatic Steatosis Using Ultrasound‐Derived Fat Fraction (CHESS2303): A Prospective Multicenter Study
- Yunlin Huang,
- Jia Li,
- Chuan Liu,
- Danlei Song,
- Chuanlong Zhu,
- Yongfeng Ren,
- Jiaojian Lv,
- Longfeng Jiang,
- Rong Shan,
- Hao Wang,
- Zhou Wang,
- Siqin Long,
- Fan Jiang,
- Xiang Xie,
- Liren Lu,
- Ruixiang Qi,
- Pengfei Rong,
- Chuxiao Shao,
- Wang Yao,
- Youfang Gao,
- Wenping Wang,
- Juan Cheng,
- Vincent Wai‐Sun Wong,
- Ying Wang,
- Wai‐Kay Seto,
- Yi Dong,
- Christoph F. Dietrich,
- Xiaolong Qi
Affiliations
- Yunlin Huang
- Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
- Jia Li
- Department of Ultrasound Zhongda Hospital Medical School Southeast University Nanjing China
- Chuan Liu
- Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- Danlei Song
- Department of Ultrasound Zhongda Hospital Medical School Southeast University Nanjing China
- Chuanlong Zhu
- Department of Infectious DiseasesThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
- Yongfeng Ren
- Department of UltrasoundBozhou Hospital Affiliated to Anhui Medical UniversityBozhouChina
- Jiaojian Lv
- Department of Liver DiseaseLishui People's HospitalLishuiChina
- Longfeng Jiang
- Department of Infectious DiseasesThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
- Rong Shan
- Department of UltrasoundShandong Public Health Clinical CenterShandong UniversityShandongChina
- Hao Wang
- Department of UltrasoundShandong Public Health Clinical CenterShandong UniversityShandongChina
- Zhou Wang
- Department of UltrasoundBozhou Hospital Affiliated to Anhui Medical UniversityBozhouChina
- Siqin Long
- Department of Liver DiseaseLishui People's HospitalLishuiChina
- Fan Jiang
- Department of Ultrasound Medicinethe Second Affiliated Hospital of Anhui Medical UniversityHefeiChina
- Xiang Xie
- Department of Interventional TherapyThe Second Affiliated Hospital of Anhui Medical UniversityHefeiChina
- Liren Lu
- Department of UltrasoundAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouChina
- Ruixiang Qi
- Department of UltrasoundAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouChina
- Pengfei Rong
- Department of RadiologyThe Third Xiangya Hospital of Central South UniversityChangshaChina
- Chuxiao Shao
- Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of LishuiLishui People's HospitalLishuiChina
- Wang Yao
- Department of UltrasoundLishui People's HospitalLishuiChina
- Youfang Gao
- Department of Infectious DiseaseThe People's Hospital of BozhouBozhouChina
- Wenping Wang
- Department of UltrasoundZhongshan HospitalFudan UniversityShanghaiChina
- Juan Cheng
- Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
- Vincent Wai‐Sun Wong
- Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina
- Ying Wang
- Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
- Wai‐Kay Seto
- Department of MedicineQueen Mary HospitalThe University of Hong KongHong KongChina
- Yi Dong
- Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
- Christoph F. Dietrich
- Department of Allgemeine Innere MedizinKliniken Hirslanden Beau SiteSalem Und PermanenceBernSwitzerland
- Xiaolong Qi
- Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- DOI
- https://doi.org/10.1002/mco2.70123
- Journal volume & issue
-
Vol. 6,
no. 3
pp. n/a – n/a
Abstract
ABSTRACT Ultrasound‐derived fat fraction (UDFF) is designed to assess the hepatic fat content quantitatively. A multicenter study that verifies the diagnostic performance of UDFF for detecting hepatic steatosis has not yet been reported. This study aimed to evaluate the performance of UDFF for diagnosing and grading hepatic steatosis. Participants referred for assessment of hepatic steatosis were prospectively recruited from eight hospitals. All participants underwent UDFF and magnetic resonance imaging proton density fat fraction (MRI‐PDFF) examinations. MRI‐PDFF was used as the reference for diagnosing hepatic steatosis. From January 2023 to July 2023, a total of 300 participants were included. The median body mass index was 25.4 kg/m2 (interquartile range: 22.7–28.1). UDFF values were positively correlated with MRI‐PDFF (R = 0.80, p < 0.001). Using MRI‐PDFF ≥ 5%, ≥ 15%, and ≥ 25% as the reference standard for detecting mild, moderate, and severe hepatic steatosis, the best cutoff values of UDFF were 7.6% (area under the receiver operating characteristic curves [AUC] = 0.90), 15.9% (AUC = 0.90), and 22.3% (AUC = 0.91), respectively. Thus, UDFF has excellent diagnostic performance in detecting and grading hepatic steatosis.
Keywords
- hepatic steatosis
- magnetic resonance imaging proton density fat fraction (MRI‐PDFF)
- noninvasive
- quantification
- ultrasound‐derived fat fraction (UDFF)
