Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India

Abstract

Background: Scarcity of data in relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) in Type 2 diabetics (T2DM), particularly in terms of gender differences. Hence, the study was aimed to investigate the gender difference in association between hyperuricemia, and NAFLD in the Indian population. Methodology: A cross-sectional study was conducted with 134 Indian adults, of which 93 males and 41were females. Among them hyperurecemics are 66 (71%) males and 26 (63%) are females. The sample was collected at the department of gastroenterology. The student t-test was applied to assess the risk of hyper and non-hyperuricemia among the NAFLD in Type-2 diabetics. Pearson correlation was used to assess link between serum uric acid and other biochemical parameters. Results: The BMI, SGOT, ALP and LDL levels are significantly elevated in hyperuricemia male subjects (P < 0.05). Triglyceride levels had a weak negative correlation with serum uric acid (SUA) levels, which was significant in male NAFLD subjects (P 0.01). The overall prevalence of hyperuricemia was more in males as compared with females (P < 0.05). Conclusion: Our results reveal that the dyslipidemia is more closely associated with hyperuricemia in men than women with NAFLD. Total cholesterol and Triglycerides showed significant weak negative correlation with SUA in males. Further longitudinal studies are required to prove these findings.

Keywords

• Serum uric acid
• NAFLD
• Type-2 diabetes
• Gender difference