Schizophrenia (Apr 2025)
Bridging Science and Hope: integrating and Communicating Lived experience in Accelerating Medicines Partnership® Schizophrenia Program
- Ameneh Asgari-Targhi,
- Beier Yao,
- Lisa Brown,
- Suzanne Garcia,
- Arundati Nagendra,
- Kota Chin,
- Tashrif Billah,
- Nora Penzel,
- Omar John,
- Nicholas Prunier,
- Simone Veale,
- Elana Kotler,
- Grace R. Jacobs,
- Ming Zhan,
- Michael J. Coleman,
- Sylvain Bouix,
- Ofer Pasternak,
- Guillermo Cecci,
- Justin T. Baker,
- Daniel H. Mathalon,
- Sinead M. Kelly,
- Cheryl M. Corcoran,
- Abraham Reichenberg,
- Inge Winter-van Rossum,
- Marek Kubicki,
- Jessica Spark,
- Dominic Dwyer,
- Celso Arango,
- Paolo Fusar-Poli,
- Monica Calkins,
- Jai L. Shah,
- Vijay Mittal,
- Andrew Thompson,
- Patrick D. McGorry,
- René S. Kahn,
- John M. Kane,
- Carrie E. Bearden,
- Scott W. Woods,
- Barnaby Nelson,
- Martha E. Shenton,
- Brandon Staglin,
- the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ),
- Carlos A. Larrauri,
- Kathryn Eve Lewandowski,
- Tina Kapur
Affiliations
- Ameneh Asgari-Targhi
- Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School
- Beier Yao
- Psychotic Disorders Division, McLean Hospital
- Lisa Brown
- Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School
- Suzanne Garcia
- National Institute of Mental Health
- Arundati Nagendra
- Schizophrenia and Psychosis Action Alliance
- Kota Chin
- Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
- Tashrif Billah
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Nora Penzel
- Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
- Omar John
- Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
- Nicholas Prunier
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Simone Veale
- Schizophrenia and Psychosis Action Alliance
- Elana Kotler
- Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
- Grace R. Jacobs
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Ming Zhan
- National Institute of Mental Health
- Michael J. Coleman
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Sylvain Bouix
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Ofer Pasternak
- Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School
- Guillermo Cecci
- IBM T.J. Watson Research Center
- Justin T. Baker
- Department of Psychiatry, Harvard Medical School
- Daniel H. Mathalon
- Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California San Francisco
- Sinead M. Kelly
- Department of Psychiatry, Brigham and Women’s Hospital and Harvard Medical School
- Cheryl M. Corcoran
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Abraham Reichenberg
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Inge Winter-van Rossum
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Marek Kubicki
- Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School
- Jessica Spark
- Orygen
- Dominic Dwyer
- Orygen
- Celso Arango
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense
- Paolo Fusar-Poli
- Department of Psychosis Studies, King’s College London
- Monica Calkins
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Jai L. Shah
- Douglas Research Centre
- Vijay Mittal
- Department of Psychology, Northwestern University
- Andrew Thompson
- Orygen
- Patrick D. McGorry
- Orygen
- René S. Kahn
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- John M. Kane
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
- Carrie E. Bearden
- Departments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of California
- Scott W. Woods
- Department of Psychiatry, Yale University School of Medicine
- Barnaby Nelson
- Orygen
- Martha E. Shenton
- Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School
- Brandon Staglin
- One Mind
- the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
- Carlos A. Larrauri
- National Alliance on Mental Illness
- Kathryn Eve Lewandowski
- Psychotic Disorders Division, McLean Hospital
- Tina Kapur
- Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41537-025-00572-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 4
Abstract
Abstract The Accelerating Medicines Partnership Schizophrenia (AMP® SCZ) program integrates lived experience into psychosis research, leveraging over three decades of foundational studies to improve research quality, promote community engagement, and ensure ethical implementation of precision psychiatry. Lived experience is embedded in the program’s governance, shaping study protocols, recruitment strategies, and digital tools such as the mindLAMP platform. Study sites also integrate lived experience through youth advisory boards, peer support specialists, and advisory committees, ensuring diverse perspectives inform research design and implementation. These efforts aim to develop predictive tools and therapeutic strategies while maintaining ethical and participant-centered practices. Advocacy organizations, such as the National Alliance on Mental Illness (NAMI), have fostered collaboration among government, industry, and academic partners, shaping outreach and engagement strategies. Dissemination efforts, led by the Website and Outreach Workgroup (WOW), include an accessible, Section 508-compliant website and co-designed resources, building trust and engagement within communities. By integrating lived experience at every stage, the program aims to foster trust, enhance research outcomes, and inform future strategies for treatment and prevention. Watch Dr. Tina Kapur, Dr. Kathryn Eve Lewandowski, and Dr. Carlos A. Larrauri discuss this article and their work at: https://vimeo.com/1050068801 .
