Preclinical translational research and application of tumor organoids

Abstract

More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied. This model is able to reproduce the genomic, transcriptome, proteome and other omics features of parental tumors without heterogeneity found in cell line models. Based on these characteristics, tumor organoids have gradually become a representative preclinical model, facilitating the translation of new research results and precision treatment of patients. This article summarizes the latest progress of tumor organoids on R&D of technology and application, focusing on the current methods of establishing tumor organoids, opportunities and challenges in clinical and research application.

Keywords

• tumor organoid|precise treatment|organoid biobank