An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa

Hao Huang; Xiaolong Shao; Yingpeng Xie; Tingting Wang; Yingchao Zhang; Xin Wang; Xin Deng

doi:10.1038/s41467-019-10778-w

Nature Communications (Jul 2019)

An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa

Hao Huang,
Xiaolong Shao,
Yingpeng Xie,
Tingting Wang,
Yingchao Zhang,
Xin Wang,
Xin Deng

Affiliations

Hao Huang: Department of Biomedical Sciences, City University of Hong Kong
Xiaolong Shao: Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University
Yingpeng Xie: Department of Biomedical Sciences, City University of Hong Kong
Tingting Wang: Department of Biomedical Sciences, City University of Hong Kong
Yingchao Zhang: Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University
Xin Wang: Department of Biomedical Sciences, City University of Hong Kong
Xin Deng: Department of Biomedical Sciences, City University of Hong Kong

DOI: https://doi.org/10.1038/s41467-019-10778-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The virulence of Pseudomonas aeruginosa is regulated by many transcriptional factors (TFs). Here, the authors study the crosstalk between 20 key virulence-related TFs, validate 347 functional target genes, and describe the regulatory relationships of the 20 TFs with their targets in a network that is available as an online platform.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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